Eastern Conference
| Classement | Equipes | Joué | Gagné | Perdu | Nuls | Différentiel | Différence de buts | Points | Forme actuelle |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Philadelphia Union |
20 | 12 | 4 | 4 | 40 - 18 | 22 | 40 | WWLWL |
| 2 |
 Toronto |
20 | 12 | 5 | 3 | 27 - 21 | 6 | 39 | LLWLL |
| 3 |
 New York City |
20 | 11 | 6 | 3 | 35 - 21 | 14 | 36 | WWWWD |
| 4 |
 Orlando City |
20 | 9 | 4 | 7 | 34 - 22 | 12 | 34 | WWLDL |
| 5 |
 Columbus Crew |
20 | 9 | 6 | 5 | 29 - 21 | 8 | 32 | WWWWW |
| 6 |
 Nashville |
23 | 8 | 7 | 8 | 24 - 22 | 2 | 32 | DLWWL |
| 7 |
 New York RB |
20 | 8 | 7 | 5 | 28 - 27 | 1 | 29 | DWLWL |
| 8 |
 New England Revolution |
20 | 7 | 7 | 6 | 24 - 24 | 0 | 27 | WLWWL |
| 9 |
 Inter Miami |
20 | 7 | 10 | 3 | 23 - 30 | -7 | 24 | LWLLW |
| 10 |
 Montréal |
20 | 7 | 11 | 2 | 29 - 38 | -9 | 23 | WLLLW |
| 11 |
 Atlanta United |
20 | 6 | 10 | 4 | 23 - 27 | -4 | 22 | LLLWL |
| 12 |
 Chicago Fire |
20 | 4 | 8 | 8 | 31 - 34 | -3 | 20 | DLDDL |
| 13 |
 DC United |
20 | 5 | 11 | 4 | 22 - 37 | -15 | 19 | WWWLL |
| 14 |
 Cincinnati |
20 | 2 | 14 | 4 | 9 - 32 | -23 | 10 | LLLLL |
Western Conference
| Classement | Equipes | Joué | Gagné | Perdu | Nuls | Différentiel | Différence de buts | Points | Forme actuelle |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Seattle Sounders |
19 | 10 | 4 | 5 | 40 - 21 | 19 | 35 | WWWWL |
| 2 |
 Dallas |
22 | 9 | 6 | 7 | 28 - 24 | 4 | 34 | WWLDL |
| 3 |
 Sporting Kansas City |
18 | 10 | 5 | 3 | 32 - 21 | 11 | 33 | WWWDL |
| 4 |
 Portland Timbers |
20 | 9 | 6 | 5 | 40 - 31 | 9 | 32 | WWLDD |
| 5 |
 Minnesota United |
18 | 8 | 5 | 5 | 32 - 23 | 9 | 29 | DWWWL |
| 6 |
 Colorado Rapids |
15 | 8 | 4 | 3 | 28 - 21 | 7 | 27 | LWWWL |
| 7 |
 Los Angeles |
19 | 8 | 8 | 3 | 36 - 32 | 4 | 27 | WWLDL |
| 8 |
 Vancouver Whitecaps |
20 | 8 | 12 | 0 | 22 - 37 | -15 | 24 | LWLLW |
| 9 |
 San Jose Earthquakes |
20 | 6 | 9 | 5 | 29 - 48 | -19 | 23 | LWWLD |
| 10 |
 LA Galaxy |
19 | 6 | 10 | 3 | 23 - 37 | -14 | 21 | LLWDL |
| 11 |
 Houston Dynamo |
20 | 4 | 9 | 7 | 25 - 34 | -9 | 19 | DDLLL |
| 12 |
 Real Salt Lake |
19 | 4 | 9 | 6 | 23 - 33 | -10 | 18 | WDLLL |
Conference Semifinals & 2021 CONCACAF Champions League
First round & 2021 Leagues Cup
First round
1/8 Final
1/4 Final
1/2 Final
Final